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NEWER DRUGS

Baloxavir marboxil MOA- Inhibit viral replication by inhibiting Cap-dependent endonuclease activity of viral polymeraseIndication - Single dose treatment of Acute uncomplicated influenza Baricitinib MOA- Janus Kinase inhibitorIndication - Rheumatoid Arthritis

NEWER DRUGS

# Tafenoquine MOA - Free radical mediated killing of hypnozooitesIndication - Single dose radical cure of P. vivax malaria # Tenapanor MOA -NHE-3 inhibitorIndication - IBS with constipation # Tolvaptan MOA -Vasopressin V2 receptor antagonistIndication - To slow kidney function decline in adult polycystic kidney disease

JVP

JVP has three upward deflections and 2 downward deflections Upward deflections : a,c and v wave Downward deflections:  x and y a wave  - Due to atrial contraction c wave – Due to bulging of tricuspid valves v wave – Due to systolic filling of the atrium x descent – Due to atrial relaxation y descent – Due to early ventricular filling Prominent a wave is seen in Pulmonary hypertension, tricuspid regurgitation Absent a wave is seen in atrial fibrillation Absent x descent seen in atrial fibrillation and tricuspid regurgitation Prominent v wave is seen in right ventricular failure and  tricuspid regurgitation Rapid y descent is seen in tricuspid regurgitation and right ventricular failure Slow y descent is seen in tricuspid stenosis